The role of Internet of Things (IoT) technologies for individualisation and service quality of a PSS

Nowadays, product manufacturers are compelled to increasingly becoming Product Service System (PSS) providers for surviving and managing the increased global competition. 20% of the enterprises have already integrated services in their product offerings. Meanwhile, the Internet of Things (IoT) is expected to grow significantly in the next years. Smart products are growing fast and are expected to reach 212 billion entities at the end of 2020. From an economic point of view, it is estimated that the impact of IoT is in a range of $2.7 to$6.2 trillion by 2025. IoT is surely an enabler of PSSs, allowing the collection and sharing of vast quantities of information along the whole solution life. This article aims to evaluate the impact that IoT technologies can have on the PSS provision when aiming at the satisfaction of highly diverting customer needs. Particularly, the analysis considers three dimensions: the typology of services enabled, the customization approach enabled, and the service quality gaps disclosed by IoT. By means of multiple use cases, the authors found out that IoT technologies have a huge impact on the different phases of the whole PSS lifecycle. Several advantages were detected for the different stakeholders involved in terms of both service efficiency and effectiveness. Based on these results, the strategic contact points to cope with possible trade-offs between the PSS individualization approach and its service quality are proposed

The impact of IoT technologies on product-oriented PSS: The 'home delivery' service case

The contribution aims to evaluate the impact that IoT technologies can have on PSS and services. Particularly, the analysis considers two dimensions: the typology of services enabled by the IoT, and the PSS lifecycle phases of the home delivery. By means of multiple use cases, authors found out that IoT technologies have huge impacts both on order placement and delivery phases. Particularly, they have a two-fold advantage for the main stakeholders involved: on one side they speed up operations and on the other they reduce the number of activities for completing the overall home delivery process

Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs.

Cannabinoids, the bioactive constituents of Cannabis sativa, and endocannabinoids, among which the most important are anandamide and 2-arachidonoylglycerol, control various biological processes by binding to specific G protein-coupled receptors, namely CB1 and CB2 cannabinoid receptors. While a vast amount of information on the mammalian endocannabinoid system does exist, few data have been reported on bony fish. In the goldfish, Carassius auratus, the CB1 receptor has been cloned and its distribution has been analyzed in the retina, brain and gonads, while CB2 had not yet been isolated. In the present paper we cloned the goldfish CB2 receptor and show that it presents a quite high degree of amino acid identity with zebrafish Danio rerio CB2A and CB2B receptors, while the percentage of identity is lower with the pufferfish Fugu rubripes CB2, as also confirmed by the phylogenetic analysis. The sequence identity becomes much lower when comparing the goldfish and the mammalian CB2 sequences; as for other species, goldfish CB2 and CB1 amino acid sequences share moderate levels of identity. Western-blotting analysis shows the CB2 receptor as two major bands of about 53 kDa and 40 kDa, and other faint bands with apparent molecular masses around 70 kDa, 57 kDa and 55 kDa. Since the distribution of a receptor could give information on its physiological role, we evaluated and compared CB1 and CB2 mRNA expression in different goldfish organs by means of quantitative Real-Time PCR. Our results show that both CB1 and CB2 receptors are widely expressed in the goldfish, displaying some tissue specificities, thus opening the way for further functional studies on bony fish and other non-mammalian vertebrates

USO DA ANÁLISE FRACTAL NA CLASSIFICAÇÃO E IDENTIFICAÇÃO DE ESPÉCIES VEGETAIS

A extensa biodiversidade das espécies vegetais existentes tornam os modelos tradicionais de classificação taxonômica uma tarefa complexa, sendo que estes são realizadas de forma manual, ocasionando aferições pouco precisas. Análise fractal tem sido utilizada como uma metodologia computacional sofisticada para a caracterização e identificação de espécies vegetais. Vascularização foliar e análise de curvatura de borda são exemplos de padrões estudados na literatura com uso da dimensão fractal. Este estudo tem como objetivo aplicar uma metodologia para identificação de espécies vegetais por meio da dimensão fractal. Neste sentido, tal grandeza foi determinada usando o método box-counting, por meio da análise da textura foliar, em quatro diferentes espécies de plantas típicas do cerrado do planalto central: Kielmeyera coriacea, Qualea parviflora, Qualea grandiflora e Annona coriacea. São coletados conjuntos distintos de amostra de folhas vegetais em duas localidades do Distrito Federal: Parque da Cidade Sarah Kubitschek e Parque Ecológico Olhos D’Água. Para análise de textura foliar, são obtidas imagens das folhas coletadas para cada espécie vegetal, baseada no processo computacional de escaneamento digital. Diferentes testes estatísticos de hipóteses são conduzidos para averiguação de tal medida como indicador de classificação com caráter taxonômico. Para cada amostra de textura de folha, uma assinatura estatística foi calculada. Os valores médios da dimensão fractal relacionados a diferentes localidades são comparados entre as espécies. Os resultados obtidos indicam diferentes valores médios para tal grandeza entre os grupos de espécies, mostrando independência em relação à localidade de coleta, caracterizando-se como um importante parâmetro no processo taxonômico para a identificação, diferenciação e classificação de espécies vegetai

Inflammatory myofibroblastic tumor of the bladder in a child: a case report

Tumores miofibroblásticos inflamatórios raramente acometem vias urinárias ou crianças, comumente mimetizando neoplasias malignas nos exames de imagem. Foram descritos apenas 35 casos desses tumores na bexiga de crianças, segundo a literatura recente. Os autores apresentam o caso de uma criança com um tumor miofibroblástico vesical que evoluiu favoravelmente após ressecção cirúrgica completa

CNF1 Improves Astrocytic Ability to Support Neuronal Growth and Differentiation In vitro

Modulation of cerebral Rho GTPases activity in mice brain by intracerebral administration of Cytotoxic Necrotizing Factor 1 (CNF1) leads to enhanced neurotransmission and synaptic plasticity and improves learning and memory. To gain more insight into the interactions between CNF1 and neuronal cells, we used primary neuronal and astrocytic cultures from rat embryonic brain to study CNF1 effects on neuronal differentiation, focusing on dendritic tree growth and synapse formation, which are strictly modulated by Rho GTPases. CNF1 profoundly remodeled the cytoskeleton of hippocampal and cortical neurons, which showed philopodia-like, actin-positive projections, thickened and poorly branched dendrites, and a decrease in synapse number. CNF1 removal, however, restored dendritic tree development and synapse formation, suggesting that the toxin can reversibly block neuronal differentiation. On differentiated neurons, CNF1 had a similar effacing effect on synapses. Therefore, a direct interaction with CNF1 is apparently deleterious for neurons. Since astrocytes play a pivotal role in neuronal differentiation and synaptic regulation, we wondered if the beneficial in vivo effect could be mediated by astrocytes. Primary astrocytes from embryonic cortex were treated with CNF1 for 48 hours and used as a substrate for growing hippocampal neurons. Such neurons showed an increased development of neurites, in respect to age-matched controls, with a wider dendritic tree and a richer content in synapses. In CNF1-exposed astrocytes, the production of interleukin 1β, known to reduce dendrite development and complexity in neuronal cultures, was decreased. These results demonstrate that astrocytes, under the influence of CNF1, increase their supporting activity on neuronal growth and differentiation, possibly related to the diminished levels of interleukin 1β. These observations suggest that the enhanced synaptic plasticity and improved learning and memory described in CNF1-injected mice are probably mediated by astrocytes

Structured reporting for fibrosing lung disease: a model shared by radiologist and pulmonologist

Objectives: To apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD). Methods: The writing committee selected the HRCT criteria\ue2\u80\u94the Delphi items\ue2\u80\u94for rating from both radiology panelists (RP) and pulmonology panelists (PP). The Delphi items were first rated by RPs as \ue2\u80\u9cessential\ue2\u80\u9d, \ue2\u80\u9coptional\ue2\u80\u9d, or \ue2\u80\u9cnot relevant\ue2\u80\u9d. The items rated \ue2\u80\u9cessential\ue2\u80\u9d by < 80% of the RP were selected for the PP rating. The format of reporting was rated by both RP and PP. Results: A total of 42 RPs and 12 PPs participated to the survey. In both Delphi round 1 and 2, 10/27 (37.7%) items were rated \ue2\u80\u9cessential\ue2\u80\u9d by more than 80% of RP. The remaining 17/27 (63.3%) items were rated by the PP in round 3, with 2/17 items (11.7%) rated \ue2\u80\u9cessential\ue2\u80\u9d by the PP. PP proposed additional items for conclusion domain, which were rated by RPs in the fourth round. Poor consensus was observed for the format of reporting. Conclusions: This study provides a template for structured report of FLD that features essential items as agreed by expert thoracic radiologists and pulmonologists

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Measurement of the correlation between the polar angles of leptons from top quark decays in the helicity basis at √s = 7 TeV using the ATLAS detector

A measurement of the correlations between the polar angles of leptons from the decay of pair-produced t and t̄ quarks in the helicity basis is reported, using proton-proton collision data collected by the ATLAS detector at the LHC. The dataset corresponds to an integrated luminosity of 4.6  fb−¹ at a center-of-mass energy of √s = 7  TeV collected during 2011. Candidate events are selected in the dilepton topology with large missing transverse momentum and at least two jets. The angles θ1 and θ2 between the charged leptons and the direction of motion of the parent quarks in the tt̄ rest frame are sensitive to the spin information, and the distribution of cosθ1 ⋅ cosθ2 is sensitive to the spin correlation between the t and t̄ quarks. The distribution is unfolded to parton level and compared to the next-to-leading order prediction. A good agreement is observed